Histopathology Atlas

WHO CLASSIFICATION OF MATURE LYMPHOID, HISTIOCYTIC AND DENDRITIC NEOPLASMS 2016

1. Mature B – cell neoplasms

   1. Chronic lymphocytic leukemia/small lymphocytic lymphoma

   2. Monoclonal B – cell lymphocytosis

   3. B – cell prolymphocytic leukemia

   4. Splenic marginal zone lymphoma

   5. Hairy cell leukemia

   6. Splenic B – cell lymphoma/leukemia, unclassifiable
      - Splenic diffuse red pulp small B – cell lymphoma
      - Hairy cell leukemia – variant

   7. Lymphoplasmacytic lymphoma
      - Waldenstrӧm macroglobulinemia

   8. Monoclonal gammopathy of undetermined significance (MGUS), IgM
      

   9. µ heavy – chain disease
      

   10. γ heavy – chain disease
       

   11. α heavy – chain disease
       

   12. Monoclonal gammopathy of undetermined significance (MGUS), IgG/A
       

   13. Plasma cell myeloma
       

   14. Solitary plasmacytoma of bone
       

   15. Extraosseous plasmacytoma
       

   16. Monoclonal immunoglobulin deposition diseases
       

   17. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
       (MALT lymphoma)
       

   18. Nodal marginal zone lymphoma
       - Pediatric nodal marginal zone lymphoma
       

   19. Follicular lymphoma
       - In situ follicular neoplasia
       - Duodenal – type follicular lymphoma
       

   20. Pediatric – type follicular lymphoma
       

   21. Large B – cell lymphoma with IRF4 rearrangement
       

   22. Primary cutaneous follicle center lymphoma
       

   23. Mantle cell lymphoma
       - In situ mantle cell neoplasia
       

   24. Diffuse large B – cell lymphoma (DLBCL), NOS
       - Germinal center B – cell type
       - Activated B – cell type
       

   25. T – cell/histiocyte – rich large B – cell lymphoma
       

   26. Primary DLBCL of the central nervous system (CNS)
       

   27. Primary cutaneous DLBCL, leg type
       

   28. EBV+ DLBCL, NOS*
       

   29. EBV+ mucocutaneous ulcer
       

   30. DLBCL associated with chronic inflammation
       

   31. Lymphomatoid granulomatosis
       

   32. Primary mediastinal (thymic) large B – cell lymphoma
       

   33. Intravascular large B – cell lymphoma
       

   34. ALK1+ large B – cell lymphoma
       

   35. Plasmablastic lymphoma
       

   36. Primary effusion lymphoma
       

   37. HHV8+ DLBCL, NOS
       

   38. Burkitt lymphoma
       

   39. Burkitt – like lymphoma with 11q aberration
       

   40. High – grade B – cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements
       

   41. High – grade B – cell lymphoma, NOS
       

   42. B – cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

2. Mature T and NK neoplasms

   1. T – cell prolymphocytic leukemia
      

   2. T – cell large granular lymphocytic leukemia

   3. Chronic lymphoproliferative disorder of NK cells

   4. Aggressive NK – cell leukemia

   5. Systemic EBV+ T – cell lymphoma of childhood

   6. Hydroa vacciniforme – like lymphoproliferative disorder
      

   7. Adult T – cell leukemia/lymphoma
      

   8. Extranodal NK –/T – cell lymphoma, nasal type
      

   9. Enteropathy – associated T – cell lymphoma
      

   10. Monomorphic epitheliotropic intestinal T – cell lymphoma
       

   11. Indolent T – cell lymphoproliferative disorder of the GI tract
       

   12. Hepatosplenic T – cell lymphoma
       

   13. Subcutaneous panniculitis – like T – cell lymphoma
       

   14. Mycosis fungoides
       

   15. Sézary syndrome
       

   16. Primary cutaneous CD30+ T – cell lymphoproliferative disorders
       - Lymphomatoid papulosis
       - Primary cutaneous anaplastic large cell lymphoma
       

   17. Primary cutaneous γδ T – cell lymphoma
       

   18. Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T – cell lymphoma
       

   19. Primary cutaneous acral CD8+ T – cell lymphoma
       

   20. Primary cutaneous CD4+ small/medium T – cell lymphoproliferative disorder
       

   21. Peripheral T – cell lymphoma, NOS
       

   22. Angioimmunoblastic T – cell lymphoma
       

   23. Follicular T – cell lymphoma
       

   24. Nodal peripheral T – cell lymphoma with TFH phenotype
       

   25. Anaplastic large – cell lymphoma, ALK+
       

   26. Anaplastic large – cell lymphoma, ALK2-
       

   27. Breast implant – associated anaplastic large – cell lymphoma

3. Hodgkin lymphoma

   1. Nodular lymphocyte predominant Hodgkin lymphoma

   2. Classical Hodgkin lymphoma
      - Nodular sclerosis classical Hodgkin lymphoma
      - Lymphocyte – rich classical Hodgkin lymphoma
      - Mixed cellularity classical Hodgkin lymphoma
      - Lymphocyte – depleted classical Hodgkin lymphoma

4. Posttransplant lymphoproliferative disorders (PTLD)

   1. Plasmacytic hyperplasia PTLD

   2. Infectious mononucleosis PTLD
      

   3. Florid follicular hyperplasia PTLD
      

   4. Polymorphic PTLD
      

   5. Monomorphic PTLD (B – and T –/NK – cell types)
      

   6. Classical Hodgkin lymphoma PTLD

5. Histiocytic and dendritic cell neoplasms

   1. Histiocytic sarcoma
      

   2. Langerhans cell histiocytosis
      

   3. Langerhans cell sarcoma
      

   4. Indeterminate dendritic cell tumor
      

   5. Interdigitating dendritic cell sarcoma
      

   6. Follicular dendritic cell sarcoma
      

   7. Fibroblastic reticular cell tumor
      

   8. Disseminated juvenile xanthogranuloma
      

   9. Erdheim – Chester disease